Mixed-race or multiethnic youth are at risk for mental and physical health problems. We used data from the National Longitudinal Study of Youth 1997 to compare family characteristics of adolescents of a mixed-race or multiethnic background with those of a monoracial or monoethnic background. Mixed-race or multiethnic youth reported feeling less supported by parents and reported less satisfactory parent-adolescent relationships. Mixed-race/multiethnic youth were more like monoracial White youth in terms of being independent but were more like racial or ethnic minorities (African Americans, Hispanics) in regard to family activities. Reasons for these findings are explored. We discuss the need for future research on the experiences of mixed-race/multiethnic youth.