Many positive youth development (PYD) programs are based on a particular PYD framework as a method for describing the program’s intention and expected outcomes. This paper presents a critical review of eight select program frameworks that are commonly used to describe PYD programs. The review reveals considerable variation in the science supporting these frameworks, with corresponding variability in their programmatic application. To account for this variation, the frameworks were grouped into three categories based on the science and context in which they were developed. After a review of the historical and organizational context for the need and use of program frameworks, we present brief reviews of the frameworks, then close by discussing implications for practice, research, and policy.